MicroRNAs are non‐coding regulators of gene expression and key factors in development, disease, and targets for bioengineering. Consequently, microRNAs have become essential elements of already burgeoning draft plant genome descriptions where their annotation is often particularly poor, contributing unduly to the corruption of public databases. Using the Citrus sinensis as an example, we highlight and review common failings of miRNAome annotations. Understanding and exploiting the role of miRNAs in plant biology will be stymied unless the research community acts decisively to (...) improve the accuracy of miRNAome annotations. We encourage genome annotation teams to do it right or not at all. (shrink)

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

The discussion of good and evil must not be confined to the sterile lecture halls of academics but related instead to ordinary human feelings, needs, and desires, says noted philosopher Richard Taylor. Efforts to understand morality by exploring human reason will always fail because we are creatures of desire as well. All morality arises from our intense and inescapable longing. The distinction between good and evil is always clouded by rationalists who convert the real problems of ethics into (...) complex philosophical puzzles. In the first part of Good and Evil, Taylor looks for a more meaningful conception by reexamining and rejecting the whole rationalistic tradition that dominates philosophical ethics. The second part provides an empirical explanation of good and evil, noting that one does not have to look too far to find prime examples of the failure of fixed moral rules. Including important commentary on Joseph Fletcher's groundbreaking situation ethics, and Aristotle's virtues (e.g., magnanimity and pride), Taylor rounds out the book by developing a philosophy of aspiration--personal worth as an ethical ideal--to replace the morality of duty. He offers a modified form of situation ethics to fit the contemporary problems we face. (shrink)

This paper reports on an ongoing ARC Discovery Project that is conducting design research into learning in collaborative virtual worlds (CVW).The paper will describe three design components of the project: (a) pedagogical design, (b)technical and graphics design, and (c) learning research design. The perspectives of each design team will be discussed and how the three teams worked together to produce the CVW. The development of productive failure learning activities for the CVW will be discussed and there will be an interactive (...) demonstration of the project's CVW. (shrink)

This text introduces readers to definitions and examples of arts-based educational research, presents tensions and questions in the field, and provides exercises for practice. It weaves together critical essays about arts-based research in the literary, visual, and performing arts with examples of artistic products of arts-based research (arts for scholarship's sake) that illuminate by example. Each artistic example is accompanied by a scholARTist's statement that includes reflection on how the work of art relates to the scholar's research interests and practices. (...) Arts-Based Research in Education: Foundations for Practice: helps the reader understand what arts-based research is - tracing the history of the field and providing examples; includes end-of-chapter questions to engage students in practicing arts-based inquiry and to generate class discussion about the material; features a diverse range of contributors -- very established scholars in educational and social science research as well those new to the field; represents a variety of voices - scholars of color, queer and straight orientations, different ages, experience, and nationalities; and presents beautiful illustrations of visual art, data-based poems, plays, short stories, and musical scores. First-of its kind, this volume is intended as a text for arts-based inquiry, qualitative research methods in education, and related courses, and as a resource for faculty, doctoral students, and scholars across the field of social science research methods. (shrink)

Al-Farabi, Avicenna and Averroes, widely known classical rationalists in the Arabic/Islamic philosophical tradition and strongly infl uential sources for Latin philosophy in the High Middle Ages, all thought themselves to be following Aristotle’s lead regarding the intellectual abstraction of intelligibles in the formation of necessary and unchanging scientific knowledge. For Aristotle it is clear that sensation is a potentiality for apprehending or coming to be individual sensed objects found in the world exterior to the human soul. This takes place by (...) way of a separation of the forms of sensibles from matter and a reception of them as an actualization of the senses of the soul. 1 In an analogous fashion, intellectual knowing is a potentiality for apprehending or coming to be in act non-individuated intellectual forms that are somehow in individuated particular sensible things. Although Aristotle says that “the objects of thought are in the sensible forms”, the analogy with sensation breaks down when it comes to the objects intellectually known. The reason for this is that the nonindividuated or universal forms of human knowledge are not in the sensibles in act as they must be in the intellect. 2 Again following Aristotle De Anima 3.4 and 3.5, these thinkers hold for a part of intellect that is passive or receptive of all things and another part that is active in making all things, this latter described as a disposition like light, this as well describing the active agent as acting like light. This second part, which the Arabic tradition called the Agent Intellect, sometimes describing it also as Active Intellect, al-‘aql al-fa‘il, was understood per Aristotelem to be an eternal cause of the intellectual forms in the human intellect. It was accepted that, without a grounding in separate eternal intellect, there may well be generalization or abstraction – in some sense of the 57term? but scientific knowledge understood as true, necessary and unchanging will not be achieved. 3 Of course, in Posterior Analytics 2.19 Aristotle writes of sensory experience and provides the image of a retreat gradually coming to a halt, saying, “The soul is so constituted that it is capable of the same sort of process”. This process somehow establishes the universal in the soul even though perception is of the particular. He describes this as taking place by induction, writing, “Clearly then it must be by induction that we acquire knowledge of the primary principles, because this is also the way in which general concepts are conveyed to us by sense-perception.” These are “first things” or primary principles or premises required by demonstration. And the Arabic tradition understood Aristotle to hold for the necessity of demonstration in the formation of scientific knowledge, something that stringently requires not only proper syllogistic form but also first premises that are known to be true, not just supposed or simply generalized on the basis of experience. 4 For the Arabic tradition, Aristotle?s doctrine of intellectual understanding required the involvement of that separate Agent Intellect to provide a solid foundation for human scientific knowledge by way of intellectual abstraction. (shrink)

Recovering Reason: Essays in Honor of Thomas L. Pangle is a collection of essays composed by students and friends of Thomas L. Pangle to honor his seminal work and outstanding guidance in the study of political philosophy. These essays examine both Socrates' and modern political philosophers' attempts to answer the question of the right life for human beings, as those attempts are introduced and elaborated in the work of thinkers from Homer and Thucydides to Nietzsche and Charles Taylor.

Bringing between two covers the most influential and accessible articles on Plato's Republic, this collection illuminates what is widely held to be the most important work of Western philosophy and political theory. It will be valuable not only to philosophers, but to political theorists, historians, classicists, literary scholars, and interested general readers.

Nietzsche's use of metaphor has been widely noted but rarely focused to explore specific images in great detail. A Nietzschean Bestiary gathers essays devoted to the most notorious and celebrated beasts in Nietzsche's work. The essays illustrate Nietzsche's ample use of animal imagery, and link it to the dual philosophical purposes of recovering and revivifying human animality, which plays a significant role in his call for de-deifying nature.

Background Institutional Review Boards (IRBs) are federally mandated to include both nonscientific and unaffiliated representatives in their membership. Despite this, there is no guidance or policy on the selection of unaffiliated or non-scientist members and reports indicate a lack of clarity regarding members’ roles. In the present study we sought to explore processes of recruitment, training, and the perceived roles for unaffiliated and non-scientist members of IRBs.Methods We distributed a self-administered REDCap survey of members of the Association for the Accreditation (...) of Human Research Protection Programs familiar with IRB member recruitment. The survey included closed and open-ended questions regarding: the operation of the HRPP/IRB(s), how unaffiliated and non-scientist members are recruited, whether they had faced challenges recruiting for these roles, and training and mentorship offered. The survey also collected information regarding the perceived value and roles of unaffiliated and non-scientist members.Results 76 responses were included in the analysis (38% completion rate). The most common approach for recruitment was referral from current IRB members, with almost half of respondents indicating challenges recruiting unaffiliated members. Over 75% indicated no additional training was provided to unaffiliated or non-scientist members compared to affiliated or scientist members. Most common supports provided were travel/parking expenses and honoraria. Commonly perceived roles were to provide an independent voice from the participant perspective, notably regarding consent processes and materials.Conclusions Respondents indicated challenges in defining unaffiliated and non-scientist members and limited practices toward recruitment and support. Future work should more closely examine the challenges in defining these roles and applying the definitions in practice, as well as strategies that may improve recruitment and retention of unaffiliated and non-scientist members. (shrink)

IT HAS BEEN characteristic of metaphysics, since the beginning of philosophy, to deny the reality of time. The characteristics ascribed to it by unreflective people, particularly that of passage, have seemed so puzzling and paradoxical that the metaphysical temperament has preferred to banish time altogether rather than embrace those paradoxes. Thus Parmenides, the earliest metaphysician, denied reality to all time and becoming, leaving his bleak and changeless conception of reality to be perfected by his pupil Zeno. Plato, too, declared that (...) reality can only be the eternal, describing the strange passage of time in which we mortals live as nothing but that eternity's moving image. Among modern philosophers Spinoza sounded the same note, being unable to think of any reality in which time, by itself, could make a difference, while Immanuel Kant reduced it to a mere form of sensibility. Among recent thinkers McTaggart comes at once to mind, with his proofs that the concept of time is simply self-contradictory. (shrink)

In this fresh evaluation of Western ethics, noted philosopher Richard Taylor argues that philosophy must return to the classical notion of virtue as the basis of ethics. To ancient Greek and Roman philosophers, ethics was chiefly the study of how individuals attain personal excellence, or "virtue," defined as intellectual sophistication, wisdom, strength of character, and creativity. With the ascendancy of the Judeo-Christian ethic, says Taylor, this emphasis on pride of personal worth was lost. Instead, philosophy became preoccupied (...) with defining right and wrong in terms of a divine lawgiver, and the concept of virtue was debased to mean mere obedience to divine law. Even today, in the absence of religious belief, modern thinkers unwittingly continue this legacy by creating hairsplitting definitions of good and evil. Taylor points out that the ancients rightly understood the ultimate concern of ethics to be the search for happiness, a concept that seems to have eluded contemporary society despite unprecedented prosperity and convenience. Extolling Aristotle's Nicomachean Ethics, Taylor urges us to reread this brilliant and still relevant treatise, especially its emphasis on an ethic of aspiration. (shrink)

After a very brief introduction, Davidson begins with an informed and detailed account of the views of Aristotle and his major commentators, whose writings had enormous influence on the development of the medieval traditions. Davidson's account is supplemented with a critical exposition of the relevant teachings from the Plotiniana Arabica, from al-Kindi, and from a treatise on the soul attributed to Porphyry in the Arabic tradition. Impressive as all this is, it is simply stage setting for Davidson's detailed accounts of (...) the doctrines and arguments of al-Farabi, Avicenna, and Averroes. (shrink)

Born in 1126 to a family of Maliki legal scholars, Ibn Rushd, known as Averroes, enjoyed a long career in religious jurisprudence at Seville and Cordoba while at the same time advancing his philosophical studies of the works of Aristotle. This translation of Averroes’ Long Commentary on Aristotle’s _De Anima_ brings to English-language readers the complete text of this influential work of medieval philosophy. Richard C. Taylor provides rich notes on the Long Commentary and a generous introduction that (...) discusses Averroes’ most mature reflections on Aristotle’s teachings as well as Averroes' comprehensive philosophical views on soul and intellect. It is only in the Long Commentary that Averroes finally resolves to his satisfaction the much vexed issue of the nature of intellect, Taylor shows. (shrink)

Al-Fârâbî’s thought on intellect was known to the Latin West through the translation of his Letter on the Intellect, through the Long Commentary on the De Anima by Averroes and through some other works. Al-Fârâbî identified the active power of intellect in Aristotle’s De Anima 3.5 as the unique and separately existing Agent Intellect, but the role of the Agent Intellect in forming intelligibles in act in the human soul is by no means unequivocally clear. Further, the apprehension of intelligibles (...) by human beings and the intellectual development of the soul, oftentimes described as an activity of abstracting (intaza`a), seems to be a genuineabstraction from experience, yet it somehow involves the emanative power of the Agent Intellect. This paper works to provide a coherent explanation of the natureof abstraction and the role of Agent Intellect in that activity. (shrink)

I shall maintain that there simply is no such thing as philosophical knowledge, nor any philosophical way of knowing anything, and defend the humble point that philosophy is, indeed, the love of wisdom. I believe the philosopher's claim to philosophical knowledge is a pretense. It is, moreover, precisely this pretense that has tended to make philosophers of today look ridiculous in the eyes of the world. With so much folly abounding, so much unhappiness even in the midst of riches, so (...) many lives seemingly wasted in the pursuit of specious ideals, men have looked hopefully to the philosophers for light upon some of those things that have always been of deep concern to thoughtful men. They have been puzzled and somewhat dismayed at what they have found. The philosophers, in turn, have been surprised to find their work the subject of considerable and unflattering editorial comment, which they have for the most part swept under the rug and out of sight. It has been a matter of genuine concern to those "outside" philosophy to realize, when wise men are sought, that not only do the philosophers not resemble very closely what they would suppose were men of great wisdom, but many do not even seem to profess a love for it. They are instead embarked upon the pursuit of philosophical knowledge—which of course no one wants to find fault with, provided there is any such thing. But what this philosophical knowledge more often than not turns out to be is either knowledge of the meanings of more or less ordinary words, facility in the techniques of logic, adeptness at definition, or felicity in saying what everyone already believes, and none of these is likely to seem to other men of mature judgment very promising of wisdom nor, indeed, even worthy of men of learning. (shrink)

Recently much interest has been shown in the notion of intelligible species in the thought of Thomas Aquinas. Intelligible species supposedly explain humanknowing of the world and universals. However, in some cases, the historical context and the philosophical sources employed by Aquinas have been sorely neglected. As a result, new interpretations have been set forth which needlessly obscure an already controversial and perhaps even philosophically tenuous doctrine. Using a recent article by Houston Smit as an example of a novel and (...) anachronistic modern interpretation of Aquinas’s abstractionism, this paper shows that Aquinas follows the intentional transference of Averroes who proposes a genuine doctrine of abstraction of intelligibles from experienced sensible particulars. The paper also shows that Aquinas uses the doctrine of primary and secondary causality from the Liber de causis when he asserts that human abstractive powers function only insofar as they are a participation in Divine illumination. (shrink)

Since nearly all the book is devoted to a systematic unraveling of the Ethics, it would be futile and pointless to try summarizing much of it. Brief attention will therefore be directed to but a few of Joachim's discussions, particularly as they bear upon controversial points of interpretation.

This article explicates Averroes's understanding of human knowing and abstraction in this three commentaries on Aristotle's De Anima. While Averroes's views on the nature of the human material intellect changes through the three commentaries until he reaches is famous view of the unity of the material intellect as one for all human beings, his view of the agent intellect as 'form for us' is sustained throughout these works. In his Long Commentary on the De Anima he reveals his dependence on (...) al-Fârâbî for this notion and provides a detailed critique of the Farabian notion that the agent intellect is 'form for us' only as agent cause, not as our true formal cause. Although Averroes argues that the agent intellect must somehow be intrinsic to us as our form since humans are per se rational and undertake acts of knowing by will, his view is shown to rest on an equivocal use of the notion of formal cause. The agent intellect cannot be properly our intrinsic formal principle while remaining ontologically separate. (shrink)

The technical advances that have enabled the development of "the cloud" have resulted in an exponential increase in the speed of information dissemination. Policy makers, sponsors of IT infrastructure and users of information and communication technologies, while being aware of the benefits of "the Cloud" as a mechanism to facilitate more efficient access to information, do not always appreciate that these developments may not always have the positive outcomes intended. University courses such as those in Social Informatics have managed to (...) keep pace with this rapid evolution of information and communication technologies and their societal impacts, but within the secondary education sector this has not always been possible, potentially creating a knowledge gap for tomorrow's policy makers. (shrink)

We present a scientific analysis of Jackson Pollock's drip paintings and show that his patterns are fractal. The analysis also shows that he refined the fractal content of his paintings over the period 1943 -- 1952. We present a novel interpretation of Pollock's work described as Fractal Expressionism -- a direct expression of the generic imagery of nature's scenery.

Abu al-Walid Muhammad ibn Ahmad ibn Muhammad ibn Rushd (ca. 1126-98), who came to be known in the Latin West as Averroes, was born at Cordoba into a family prominent for its expert devotion to the study and development of religious law (shar'ia). In Arabic sources al-Hafid (“the Grandson”) is added to his name to distinguish him from his grandfather (d. 1126), a famous Malikite jurist who served the ruling Almoravid regime as qadi (judge) and even as imam (prayer leader (...) and chief religious authority) at the magnificent Great Mosque which still stands today in the city of Averroes' birth and where Averroes himself served as Grand Qadi (chief judge). When the governing regime changed with the success of 'Abd al-Mu'min (r. 1130-63), founder of the Almohad (al-Muwahhidun) dynasty, the members of the family continued to flourish under a new religious orientation based on the teachings of the reformer, al-Mah. di ibn Tumart (d. ca. 1129-30). Although insistent on the strict adherence to religious law, Ibn Tumart's teachings were at the same time equally insistent on the essential rationality of human understanding of the existence and unity (tawhid) of God and his creation as well as the rationality of the Qur'an and its interpretation. (shrink)

In his seminal 1935 study of the internal senses in medieval2 thought, Harry Austryn Wolfson presented a detailed account of the development of the "classification and terminology" of the Greek, Arabic, Hebrew and Latin traditions on sensory powers which he called, "post-sensationary faculties,"~ that is, powers which are posterior to the five external senses. In explaining the complex development of teachings on the internal senses from Aristotle's texts, Wolfson recounted the Aristotelian understanding of Galen who specifically locates the OHXVOTl'ttKOV or (...) cogitative faculty in the middle ventricle of the brain and John of Damascus whose equally Aristotelian account follows the Stagirite in attributing judgments of goodand bad as well as combination and separation of ideas to the omvoTl'ttKTJ 'lfUXTt or the cogitative soul and to ouxvma or cogitation.4 One of the many fruits of Wolfson's discussion was an explanation of the development of the Avicennian doctrine of estimation as arising"out of a desire to supplement a deficiency which seemed to exist in Aristotle's account of the actual motion of pursuit and avoidance which is observed in both man and animal. "5 With wahm used to describe instinctive behavior consequent upon non-rational animal imagination analogous to human reasoning or deliberation, Wolfson wrote, the Arabic fikr now was tobe associated with imagination and no longer was to be seen as simply the power of combining and separating ideas. "In the case of ouivotcx combined with imagination, it is the combination and separation of images, i.e., the construction out of images of things existent, new composite images of things nonexistent, or the breaking up of images of things existent into images of things nonexistent."6 From this moment on, and not without some foundation in Aristotle's own texts as indicated, fikr/ cogitatio and their related derivative terms are used to characterize human rational powers which are essentially activities involving the bodyand bodily instruments insofar as imagination is necessarily bodily. (shrink)

Al-Fârâbî’s thought on intellect was known to the Latin West through the translation of his Letter on the Intellect, through the Long Commentary on the De Anima by Averroes and through some other works. Al-Fârâbî identified the active power of intellect in Aristotle’s De Anima 3.5 as the unique and separately existing Agent Intellect, but the role of the Agent Intellect in forming intelligibles in act in the human soul is by no means unequivocally clear. Further, the apprehension of intelligibles (...) by human beings and the intellectual development of the soul, oftentimes described as an activity of abstracting , seems to be a genuineabstraction from experience, yet it somehow involves the emanative power of the Agent Intellect. This paper works to provide a coherent explanation of the natureof abstraction and the role of Agent Intellect in that activity. (shrink)

456 JOURNAL OF THE HISTORY or PHILOSOPHY 34:3 JULY 1996 of reflection about rhetorical practices that I suspect Aristotle was trying to elicit in his own time and that Garver is trying to elicit in his. DAVID J. DEPEW California State University, FuUerton Fran O'Rourke, Pseudo-Dionysius and the Metaphysics of Aquinas. Leiden: E.J. Brill, 1999. Pp. xvi + 3oo. Cloth, $8o.oo. The importance of doctrines found in the Latin translations of the late fifth-century Greek works of pseudo-Dionysius the Areopagite for (...) the formation of the theologi- cal and philosophical thought of Thomas Aquinas is obvious to anyone well-versed in the texts of Aquinas. However, it is by no means obvious how Aquinas read, under- stood, and transformed the Christian Neoplatonic theology of this apparent disciple of Proclus or Damascius so as to make it an integral part of his understanding of God and creation. O'Rourke rightly conceived his task as twofold: first, the texts of Dionysius must be properly understood; second, the interpretation and use of these by Aquinas can itself be assessed and appreciated in its own thirteenth-century con- text. In the first part of the book he examines the question of knowledge of God, with one chapter devoted to Dionysius and a second devoted to Aquinas's use of "Dionysian Elements" in discovering God. Part Two examines their teachings on the "Transcendence of Being and Good" in chapters 3 and 4. Part Three contains three chapters on the "Unity.. (shrink)

The utilitarian fallacy, most egregiously committed by J. S. Mill but perpetuated ever since, consists of supposing that “pleasure”, being a noun, is, in every true statement in which it occurs, the name of a feeling, and that “pleasant”, in any such statement, means that whatever is so described is conducive to that feeling. In fact, “pleasant” is more commonly used as a positive term of appraisal, indicating that the thing so described is liked, and usually liked for its own (...) sake, and “pleasure” typically has a similar use. These terms thus resemble words like “awful”, “wonderful” and so on, which typically do not mean evocative of awe, wonder and so on. What follows from this is that the feeling of pleasure, while perhaps good for its own sake, is not uniquely so. Almost anything correctly described as pleasant is apt to be such. Similar observations apply to the term “happiness”. Therefore utilitarianism, according to which there is only one thing good as an end, or for its own sake - namely, pleasure or happiness - is false as a philosophical theory of ethics. (shrink)

Historically, republicans were of different minds about markets: some, such as Rousseau, reviled them, while others, like Adam Smith, praised them. The recent republican resurgence has revived this issue. Classical liberals such as Gerald Gaus contend that neo-republicanism is inherently hostile to markets, while neo-republicans like Richard Dagger and Philip Pettit reject this characterization—though with less enthusiasm than one might expect. I argue here that the right republican attitude toward competitive markets is celebratory rather than acquiescent and that republicanism (...) demands such markets for the same reason it requires the rule of law: because both are essential institutions for protecting individuals from arbitrary interference. I reveal how competition restrains—and in the limit, even eradicates—market power and thereby helps us realize “market freedom,” i.e., freedom as non-domination in the context of economic exchange. Finally, I show that such freedom necessitates “Anglo-Nordic” economic policies. (shrink)

Do our lives have meaning? Should we create more people? Is death bad? Should we commit suicide? Would it be better to be immortal? Should we be optimistic or pessimistic? Since Life, Death, and Meaning: Key Philosophical Readings on the Big Questions first appeared, David Benatar's distinctive anthology designed to introduce students to the key existential questions of philosophy has won a devoted following among users in a variety of upper-level and even introductory courses.